Pain and Inflammation

We are not accepting new applicants for this study until further notice.

 

Background Statement:

Inflammation is an essential part of everyday life. Generally, acute inflammation is good and is in response to tissue trauma or infection. Sometimes our immune system overreacts and continues to produce mediators of inflammation beyond our bodyís acute needs. This is chronic inflammation. Chronic inflammation usually makes a disease condition worse. Common mediators of inflammation include substances called cytokines, interleukins and other autacoids such as leukotrienes and histamine.

Chronic inflammation is usually a part of a continuing disease process and may be considered a co-morbidity of disease or a component of a more complex, multifactorial, disease such as:

  • RA or OA.
  • Lung diseases such as asthma or COPD.
  • Heart disease such as CHF.
  • Chronic kidney disease or a vascular disease such as atherosclerosis.
  • Chronic neurological diseases such as Alzheimerís Disease and Parkinsonís Disease.

Scientists believe that if we can slow or stop this chronic over reactive inflammatory process we can stop the progression of many chronic diseases.

Drugs commonly used to treat chronic inflammation, and associated pain, include:

  • Non-prescription products such as aspirin and ibuprofen.
  • Physician prescribed products including NSAIDS such as diclofenac.
  • DHFR inhibitors such as methotrexate.
  • TNF antagonists such as enbrel.

These drug products are effective but are associated with many serious side effects including:

  • Gastric and duodenal ulcer formation.
  • Pulmonary fibrosis.
  • Side effects associated with liver and kidney function.

While it is important to decrease inflammation, because inflammation will just make the disease more severe, it is also very important to limit the exposure of our bodies to these drugs. Not only can they be very expensive, especially TNF antagonists, but, in some cases, they have serious side effects such as pulmonary fibrosis, neuropathy, gastrointestinal side effects and addiction.

If you suffer from chronic diseases of inflammation, we recommend that you enroll in an all natural and safe approach to reduce your aches and pains. If you are accepted into this study, you will be asked to take daily, a high dose strength proprietary formulation of omega-3 oil, formulated to optimize absorption and effectiveness and also containing a mixture of all natural and safe COX inhibitors. This product can be taken once daily as an adjunct to your standard physician prescriptions.

The aim of this study is to assess the value (efficacy) of high potency omega-3 oil to treat pain and inflammation as a stand alone agent or when given with standard drugs (OTC or prescribed). We believe that our high potency oils will allow patients to decrease their standard medication (frequency of use or dose strength) with superior control of pain and inflammation and with less drug induced side effects. For this reason, patients should experience less pain and require lower doses of medication to control pain caused by inflammation.

If you would like to participate in this study please review our specific enrollment forms. If you are accepted into this study, we will notify you via email.

If you have any questions, please email studydirector@nprine.org